Quantifying Allowable Motion to Achieve Safe Dose Escalation in Pancreatic SBRT.

ABSTRACT:

Purpose

Tumor motion plays a key role in the safe delivery of stereotactic body radiation therapy (SBRT) for pancreatic cancer. The purpose of this study was to use tumor motion measured in patients to establish limits on motion magnitude for safe delivery of pancreatic SBRT and to help guide motion-management decisions in potential dose-escalation scenarios.

Methods and materials

Using 91 sets of pancreatic tumor motion data, we calculated the motion-convolved dose of the gross tumor volume, duodenum, and stomach for 25 patients with pancreatic cancer. We derived simple linear or quadratic models relating motion to changes in dose and used these models to establish the maximum amount of motion allowable while satisfying error thresholds on key dose metrics. In the same way,

SUBMITTER: Ding Y 

PROVIDER: S-EPMC6592725 | biostudies-literature | 2019 Jul - Aug

REPOSITORIES: biostudies-literature