Early childhood trauma alters neurological responses to mental stress in patients with coronary artery disease.

ABSTRACT:

Background

Early childhood trauma is known to independently increase adverse outcome risk in coronary artery disease (CAD) patients, although the neurological correlates are not well understood. The purpose of this study was to examine whether early childhood trauma alters neural responses to acute mental stress in CAD patients.

Methods

Participants (n = 152) with CAD underwent brain imaging with High Resolution Positron Emission Tomography and radiolabeled water during control (verbal counting, neutral speaking) and mental stress (mental arithmetic, public speaking). Traumatic events in childhood were assessed with the Early Trauma Inventory (ETI-SR-SF) and participants were separated by presence (ETI+) or absence (ETI-) of early childhood trauma. Brain activity during ment

SUBMITTER: Wittbrodt MT 

PROVIDER: S-EPMC6592739 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature