Elimination of peripheral auditory pathway activation does not affect motor responses from ultrasound neuromodulation.

ABSTRACT:

Background

Recent studies in a variety of animal models including rodents, monkeys, and humans suggest that transcranial focused ultrasound (tFUS) has considerable promise for non-invasively modulating neural activity with the ability to target deep brain structures. However, concerns have been raised that motor responses evoked by tFUS may be due to indirect activation of the auditory pathway rather than direct activation of motor circuits.

Objective

In this study, we sought to examine the involvement of peripheral auditory system activation from tFUS stimulation applied to elicit motor responses. The purpose was to determine to what extent ultrasound induced auditory artifact could be a factor in ultrasound motor neuromodulation.

Methods

In this study, tFUS-induced

SUBMITTER: Mohammadjavadi M 

PROVIDER: S-EPMC6592746 | biostudies-literature | 2019 Jul - Aug

REPOSITORIES: biostudies-literature