Differential inflammatory response dynamics in normal lung following stereotactic body radiation therapy with protons versus photons.

ABSTRACT:

Background and purpose

To compare time-dependent changes in lung parenchyma of early-stage non-small cell lung carcinoma (NSCLC) patients after stereotactic body radiation therapy with protons (SBPT) or photons (SBRT).

Materials and method

We retrospectively identified NSCLC patients treated with SBPT and matched each one with a SBRT patient by patient, tumor, and treatment characteristics. Lung parenchyma on serial post-treatment chest computer tomography (CT) scans was deformably registered with the treatment plan to analyze lung density changes as function of dose, quantified by Houndsfield Unit (HU)/Gy. A thoracic radiologist also evaluated the CTs using an established grading system.

Results

We matched 23 SBPT/SBRT pairs, including 5 patients treated with both mo

SUBMITTER: Li Y 

PROVIDER: S-EPMC6592748 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature