Circulating Inflammation Proteins Associated With Lung Cancer in African Americans.

ABSTRACT:

Introduction

Lung cancer incidence is higher among African Americans (AAs) compared with European Americans (EAs) in the United States. We and others have previously shown a relationship between immune and inflammation proteins with lung cancer in EAs. Our aim was to investigate the etiologic relationship between inflammation and lung cancer in AAs.

Methods

We adopted a two-stage, independent study design (discovery cases, n = 316; control cases, n = 509) (validation cases, n = 399; control cases, n = 400 controls) and measured 30 inflammation proteins in blood using Meso Scale Discovery V- PLEX multiplex assays.

Results

We identified and validated 10 proteins associated with lung cancer in AAS, some that were common between EAs and AAs (C-reactive proteins [OR: 2.90;

SUBMITTER: Meaney CL 

PROVIDER: S-EPMC6592767 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature