Prenatal and postnatal inflammation-related risk factors for retinopathy of prematurity.

ABSTRACT:

Objective

To evaluate the relationship between prenatal and postnatal inflammation-related risk factors and severe retinopathy of prematurity (ROP).

Study design

The study included infants born <30 weeks in California from 2007 to 2011. Multivariable log-binomial regression was used to assess the association between prenatal and postnatal inflammation-related exposures and severe ROP, defined as stage 3-5 or surgery for ROP.

Results

Of 14,816 infants, 10.8% developed severe ROP. Though prenatal inflammation-related risk factors were initially associated with severe ROP, after accounting for the effect of these risk factors on gestational age at birth through mediation analysis, the association was non-significant (P = 0.6). Postnatal factors associated with severe ROP

SUBMITTER: Goldstein GP 

PROVIDER: S-EPMC6592770 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature