Role of Tumor Pericytes in the Recruitment of Myeloid-Derived Suppressor Cells.

ABSTRACT:

Background

Pericytes are members of the tumor stroma; however, little is known about their origin, function, or interaction with other tumor components. Emerging evidence suggest that pericytes may regulate leukocyte transmigration. Myeloid-derived suppressor cells (MDSC) are immature myeloid cells with powerful inhibitory effects on T-cell-mediated antitumor reactivity.

Methods

We generated subcutaneous tumors in a genetic mouse model of pericyte deficiency (the pdgfb (ret/ret) mouse) and littermate control mice (n = 6-25). Gene expression profiles from 253 breast cancer patients (stage I-III) were evaluated for clinic-pathological parameters and survival using Cox proportional hazard ratios (HRs) and 95% confidence intervals (CIs) based on a two-sided Wald test.

Results

SUBMITTER: Hong J 

PROVIDER: S-EPMC6592827 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature