Bradykinin increases BP in endotoxemic rat: functional and biochemical evidence of angiotensin II AT₁ /bradykinin B₂ receptor heterodimerization.

ABSTRACT:

Background and purpose

Bradykinin may induce vasoconstriction in selected vessels or under specific experimental conditions. We hypothesized that inflammatory stimuli, such as endotoxin challenge, may induce the dimerization of AT₁ /B₂ receptors, altering the vascular effects of bradykinin.

Experimental approach

Wistar rats received LPS (1 mg·kg^-1 , i.p.) and were anaesthetized for assessment of BP. Mesenteric resistance arteries were used in organ baths and subjected to co-immunoprecipitation and Western blot analyses.

Key results

At 24 and 48 hr after LPS, bradykinin-induced hypotension was followed by a sustained increase in BP, which was not found in non-endotoxemic animals. The B₂ receptor antagonist Hoe-140 fully block

SUBMITTER: Anton EL 

PROVIDER: S-EPMC6592862 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature