Lzts1 controls both neuronal delamination and outer radial glial-like cell generation during mammalian cerebral development.

ABSTRACT: In the developing central nervous system, cell departure from the apical surface is the initial and fundamental step to form the 3D, organized architecture. Both delamination of differentiating cells and repositioning of progenitors to generate outer radial glial cells (oRGs) contribute to mammalian neocortical expansion; however, a comprehensive understanding of their mechanisms is lacking. Here, we demonstrate that Lzts1, a molecule associated with microtubule components, promotes both cell departure events. In neuronally committed cells, Lzts1 functions in apical delamination by altering apical junctional organization. In apical RGs (aRGs), Lzts1 expression is variable, depending on Hes1 expression levels. According to its differential levels, Lzts1 induces diverse RG behaviors: planar

SUBMITTER: Kawaue T 

PROVIDER: S-EPMC6592889 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature