Genomic analysis reveals variant association with high altitude adaptation in native chickens.

ABSTRACT: Native chickens are endangered genetic resources that are kept by farmers for different purposes. Native chickens distributed in a wide range of altitudes, have developed adaptive mechanisms to deal with hypoxia. For the first time, we report variants associated with high-altitude adaptation in Iranian native chickens by whole genome sequencing of lowland and highland chickens. We found that these adaptive variants are involved in DNA repair, organs development, immune response and histone binding. Amazingly, signature selection analysis demonstrated that differential variants are adaptive in response to hypoxia and are not due to other evolutionary pressures. Cellular component analysis of variants showed that mitochondrion is the most important organelle for hypoxia adaptation. A total o

SUBMITTER: Kharrati-Koopaee H 

PROVIDER: S-EPMC6592930 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature