Proniosomal gel for transdermal delivery of lornoxicam: optimization using factorial design and in vivo evaluation in rats.

ABSTRACT:

Objective

Clinical utility of lornoxicam in oral therapy is primarily restricted by the low solubility and gastric adverse effects. This study evaluated the prospective of optimized proniosomal gel to improve the clinical efficacy of lornoxicam and compare with oral therapy.

Methods

Proniosomes were formulated by coacervation phase separation technique using span 60, lecithin and cholesterol. A four-factor three-level Box-Behnken design was used to evaluate the effect of amount of four independent variables; span 60 (X₁), cholesterol (X₂), lecithin (X₃) and lornoxicam (X₄) on response variables; vesicle size (Y₁), entrapment efficiency (Y₂) and transdermal flux (Y₃). The selected proniosomal gel (F1

SUBMITTER: Shah H 

PROVIDER: S-EPMC6593013 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature