Therapeutic approaches for neonatal abstinence syndrome: a systematic review of randomized clinical trials.

ABSTRACT: Neonatal abstinence syndrome (NAS) which is observed in 55-94% of the newborns from opioids-taking mothers produces deleterious neurological symptoms. Various pharmacological therapies have been investigated in neonates with NAS. This article reviews all studies on NAS treatment to analyze the duration of treatment, length of hospitalization and possible drug adverse effects. The search was limited to the randomized clinical trials which examined the treatments of neonates with NAS. Scientific databases including PubMed, Cochrane Library, ISI Web of Science, Embase and Scopus were systematically searched. Retrieved articles were reviewed by two researchers and evaluated using the JADAD scoring system. Finally, the treatment duration, hospitalization length and drug side-effects were extrac

SUBMITTER: Ghazanfarpour M 

PROVIDER: S-EPMC6593026 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature