MiRNome Reveals New Insights Into the Molecular Biology of Field Cancerization in Gastric Cancer.

ABSTRACT:

Background

MicroRNAs (miRNAs) play an important role in gastric carcinogenesis and have been associated with gastric field cancerization; however, their role is not fully understood in this process. We performed the miRNome sequencing of non-cancerous, adjacent to tumor and gastric cancer samples to understand the involvement of these small RNAs in gastric field cancerization.

Methods

We analyzed samples of patients without cancer as control (non-cancerous gastric samples) and adjacent to cancer and gastric cancer paired samples, and considered miRNAs with |log₂(fold change)| > 2 and Padj < 0.05 to be statistically significant. The identification of target genes, functional analysis and enrichment in KEGG pathways were realized in the TargetCompare,

SUBMITTER: Pereira A 

PROVIDER: S-EPMC6593062 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature