Finding Friends in the Crowd: Three-Dimensional Cliques of Topological Genomic Domains.

ABSTRACT: The mammalian genome is intricately folded in a three-dimensional topology believed to be important for the orchestration of gene expression regulating development, differentiation and tissue homeostasis. Important features of spatial genome conformation in the nucleus are promoter-enhancer contacts regulating gene expression within topologically-associated domains (TADs), short- and long-range interactions between TADs and associations of chromatin with nucleoli and nuclear speckles. In addition, anchoring of chromosomes to the nuclear lamina via lamina-associated domains (LADs) at the nuclear periphery is a key regulator of the radial distribution of chromatin. To what extent TADs and LADs act in concert as genomic organizers to shape the three-dimensional topology of chromatin has long

SUBMITTER: Collas P 

PROVIDER: S-EPMC6593077 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature