Active Tonic mTORC1 Signals Shape Baseline Translation in Naive T Cells.

ABSTRACT: Naive CD4⁺ T cells are an example of dynamic cell homeostasis: T cells need to avoid autoreactivity while constantly seeing self-peptides, yet they must be primed to react to foreign antigens during infection. The instructive signals that balance this primed yet quiescent state are unknown. Interactions with self-peptides result in membrane-proximal, tonic signals in resting T cells. Here we reveal selective and robust tonic mTORC1 signals in CD4⁺ T cells that influence T cell fate decisions. We find that the Ras exchange factor Rasgrp1 is necessary to generate tonic mTORC1 signals. Genome-wide ribosome profiling of resting, primary CD4⁺ T cells uncovers a baseline translational landscape rich in mTOR targets linked to mitochondria, oxidative phosphorylatio

SUBMITTER: Myers DR 

PROVIDER: S-EPMC6593126 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature