Hepatocyte Peroxisome Proliferator-Activated Receptor α Enhances Liver Regeneration after Partial Hepatectomy in Mice.

ABSTRACT: Peroxisome proliferator-activated receptor α (PPARα) is a key nuclear receptor involved in the control of lipid homeostasis. In rodents, PPARα is also a potent hepatic mitogen. Hepatocyte-specific disruption of PPARα inhibits agonist-induced hepatocyte proliferation; however, little is known about the exact role of PPARα in partial hepatectomy (PHx)-induced liver regeneration. Herein, using hepatocyte-specific PPARα-deficient (Ppara^ΔHep) mice, the function of hepatocyte PPARα in PHx-induced liver regeneration was investigated. PPARα protein level and transcriptional activity were increased in the liver after PHx. Compared with the Ppara^fl/fl mice, Ppara^ΔHep mice exhibited significantly reduced hepatocyte proliferation at 32 hours after PHx. Consistently, re

SUBMITTER: Xie G 

PROVIDER: S-EPMC6593252 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature