Micronutrient Requirements and Sharing Capabilities of the Human Gut Microbiome.

ABSTRACT: The human gut microbiome harbors a diverse array of metabolic pathways contributing to its development and homeostasis via a complex web of diet-dependent metabolic interactions within the microbial community and host. Genomics-based reconstruction and predictive modeling of these interactions would provide a framework for diagnostics and treatment of dysbiosis-related syndromes via rational selection of therapeutic prebiotics and dietary nutrients. Of particular interest are micronutrients, such as B-group vitamins, precursors of indispensable metabolic cofactors, that are produced de novo by some gut bacteria (prototrophs) but must be provided exogenously in the diet for many other bacterial species (auxotrophs) as well as for the mammalian host. Cross-feeding of B vitamins betwee

SUBMITTER: Rodionov DA 

PROVIDER: S-EPMC6593275 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature