Genomic Characterization of the Emerging Pathogen Streptococcus pseudopneumoniae.

ABSTRACT: Streptococcus pseudopneumoniae is a close relative of the major human pathogen S. pneumoniae It is increasingly associated with lower-respiratory-tract infections (LRTI) and a high prevalence of antimicrobial resistance (AMR). S. pseudopneumoniae is difficult to identify using traditional typing methods due to similarities with S. pneumoniae and other members of the mitis group (SMG). Using whole-genome sequencing of LRTI isolates and a comparative genomic approach, we found that a large number of pneumococcal virulence and colonization genes are present in the core S. pseudopneumoniae genome. We also reveal an impressive number of novel surface-exposed proteins encoded by the genome of this species. In addition, we propose a new and entirely specific mol

SUBMITTER: Garriss G 

PROVIDER: S-EPMC6593409 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature