Systematic review with meta-analysis: risk factors for recurrent primary sclerosing cholangitis after liver transplantation.

ABSTRACT:

Background

After liver transplantation primary sclerosing cholangitis (PSC), the condition returns in the transplanted liver in a subset of patients (recurrent primary sclerosing cholangitis, rPSC).

Aim

To define risk factors for rPSC.

Methods

We searched Pubmed, Embase, Web of Science, and Cochrane library for articles published until March 2018. Studies addressing risk factors for developing rPSC were eligible for inclusion. A random effects meta-analysis was conducted using hazard ratios (HR) as effect measure. Study quality was evaluated with the Newcastle Ottawa scale. Statistical analysis was performed using Cochrane Review Manager.

Results

The electronic database search yielded 449 results. Twenty-one retrospective cohort studies met the inclusion criter

SUBMITTER: Steenstraten IC 

PROVIDER: S-EPMC6593422 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature