Heterogeneity in the treatment of bloodstream infections identified from antibiotic exposure mapping.

ABSTRACT:

Purpose

As changes in antibiotic therapy are common, intent-to-treat and definitive therapy exposure definitions in infectious disease clinical trials and observational studies may not accurately reflect all antibiotics received over the course of the infection. Therefore, we sought to describe changes in antibiotic therapy and unique treatment patterns among patients with bacteremia.

Methods

We conducted a retrospective cohort study of hospitalizations from Veterans Affairs (VA) Medical Centers (January 2002-September 2015) and community hospitals (de-identified Optum Clinformatics DataMart with matched Premier Hospital data; October 2009-March 2013). In the VA population, antibiotic exposures were mapped from the culture collection date among those with positive Staphyloco

SUBMITTER: Caffrey AR 

PROVIDER: S-EPMC6593441 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature