Optimized fractionated radiotherapy with anti-PD-L1 and anti-TIGIT: a promising new combination.

ABSTRACT:

Purpose/objective

Radiotherapy (RT) induces an immunogenic antitumor response, but also some immunosuppressive barriers. It remains unclear how different fractionation protocols can modulate the immune microenvironment. Clinical studies are ongoing to evaluate immune checkpoint inhibitors (ICI) in association with RT. However, only few trials aim to optimize the RT fractionation to improve efficacy of these associations. Here we sought to characterize the effect of different fractionation protocols on immune response with a view to associating them with ICI.

Materials/methods

Mice bearing subcutaneous CT26 colon tumors were irradiated using a SARRP device according to different radiation schemes with a same biologically effective dose. Mice were monitored for tumor growth. T

SUBMITTER: Grapin M 

PROVIDER: S-EPMC6593525 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature