High-fat diet-induced obesity causes an inflammatory microenvironment in the kidneys of aging Long-Evans rats.

ABSTRACT:

Background

Obesity is a risk factor for chronic kidney disease (CKD). While the exact mechanisms remain unclear, inflammation may be a consequence of obesity that directly impacts the kidneys. The aim of this study was to examine the inflammatory status of the kidneys and potential ongoing renal damage, i.e., tubular damage and fibrosis after long-term obesity maintained through persistent consumption of a high-fat diet (HFD).

Results

Twenty-four-week-old male Long-Evans (LEV) rats were continuously fed a control diet (CD) or HFD for 51 weeks. The mean body weight was higher in HFD-fed rats than in control diet-fed rats and markedly elevated during the last 24 weeks. Blood analyses revealed no substantial alterations in renal functional parameters by HFD consumption but a su

SUBMITTER: Laurentius T 

PROVIDER: S-EPMC6593534 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature