Fused in sarcoma silences HIV gene transcription and maintains viral latency through suppressing AFF4 gene activation.

ABSTRACT:

Background

The human immunodeficiency virus (HIV) cell reservoir is currently a main obstacle towards complete eradication of the virus. This infected pool is refractory to anti-viral therapy and harbors integrated proviruses that are transcriptionally repressed but replication competent. As transcription silencing is key for establishing the HIV reservoir, significant efforts have been made to understand the mechanism that regulate HIV gene transcription, and the role of the elongation machinery in promoting this step. However, while the role of the super elongation complex (SEC) in enhancing transcription activation of HIV is well established, the function of SEC in modulating viral latency is less defined and its cell partners are yet to be identified.

Results

In this stu

SUBMITTER: Krasnopolsky S 

PROVIDER: S-EPMC6593535 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature