Cortical thickness and cognitive performance in asymptomatic unilateral carotid artery stenosis.

ABSTRACT:

Background

We investigated changes of cortical thickness and its association with cognitive performance in patients with high-grade carotid artery stenosis without ischemic brain lesions.

Methods

We studied 25 patients with unilateral carotid artery stenosis ≥50% and 25 age-matched controls. All subjects underwent T1-weighted MRI, and cortical thickness was measured in 33 regions of interest in each hemisphere, as well as in brain regions belonging to the vascular territory of the middle cerebral artery (MCA). General linear mixed models were fitted to the dependent variable cortical thickness. Cognitive assessment comprised the Stroop Test and Trail Making Test B.

Results

In the linear mixed model, presence of carotid stenosis had no effect on cortical thickness. The

SUBMITTER: Nickel A 

PROVIDER: S-EPMC6593546 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature