Identification of sex determination genes and their evolution in Phlebotominae sand flies (Diptera, Nematocera).

ABSTRACT:

Background

Phlebotomine sand flies (Diptera, Nematocera) are important vectors of several pathogens, including Leishmania parasites, causing serious diseases of humans and dogs. Despite their importance as disease vectors, most aspects of sand fly biology remain unknown including the molecular basis of their reproduction and sex determination, aspects also relevant for the development of novel vector control strategies.

Results

Using comparative genomics/transcriptomics data mining and transcriptional profiling, we identified the sex determining genes in phlebotomine sand flies and proposed the first model for the sex determination cascade of these insects. For all the genes identified, we produced manually curated gene models, developmental gene expression profile and perfo

SUBMITTER: Petrella V 

PROVIDER: S-EPMC6593557 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature