MiR-221-5p regulates proliferation and migration in human prostate cancer cells and reduces tumor growth in vivo.

ABSTRACT:

Background

Despite latest advances in prostate cancer (PCa) therapy, PCa remains the third-leading cause of cancer-related death in European men. Dysregulation of microRNAs (miRNAs), small non-coding RNA molecules with gene expression regulatory function, has been reported in all types of epithelial and haematological cancers. In particular, miR-221-5p alterations have been reported in PCa.

Methods

miRNA expression data was retrieved from a comprehensive publicly available dataset of 218 PCa patients (GSE21036) and miR-221-5p expression levels were analysed. The functional role of miR-221-5p was characterised in androgen- dependent and androgen- independent PCa cell line models (C4-2 and PC-3M-Pro4 cells) by miR-221-5p overexpression and knock-down experiments. The metastati

SUBMITTER: Kiener M 

PROVIDER: S-EPMC6593572 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature