Discriminative Accuracy of FEV1:FVC Thresholds for COPD-Related Hospitalization and Mortality.

ABSTRACT:

Importance

According to numerous current guidelines, the diagnosis of chronic obstructive pulmonary disease (COPD) requires a ratio of the forced expiratory volume in the first second to the forced vital capacity (FEV1:FVC) of less than 0.70, yet this fixed threshold is based on expert opinion and remains controversial.

Objective

To determine the discriminative accuracy of various FEV1:FVC fixed thresholds for predicting COPD-related hospitalization and mortality.

Design, setting, and participants

The National Heart, Lung, and Blood Institute (NHLBI) Pooled Cohorts Study harmonized and pooled data from 4 US general population-based cohorts (Atherosclerosis Risk in Communities Study; Cardiovascular Health Study; Health, Aging, and Body Composition Study; and Multi-Ethn

SUBMITTER: Bhatt SP 

PROVIDER: S-EPMC6593636 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature