Association of Midlife Cardiovascular Risk Profiles With Cerebral Perfusion at Older Ages.

ABSTRACT:

Importance

Poor cardiovascular health is an established risk factor for dementia, but little is known about its association with brain physiology in older adults.

Objective

To examine the association of cardiovascular risk factors, measured repeatedly during a 20-year period, with cerebral perfusion at older ages.

Design, setting, and participants

In this longitudinal cohort study, individuals were selected from the Whitehall II Imaging Substudy. Participants were included if they had no clinical diagnosis of dementia, had no gross brain structural abnormalities on magnetic resonance imaging scans, and had received pseudocontinuous arterial spin labeling magnetic resonance imaging. Cardiovascular risk was measured at 5-year intervals across 5 phases from September 199

SUBMITTER: Suri S 

PROVIDER: S-EPMC6593638 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature