Rate of Memory Change Before and After Cancer Diagnosis.

ABSTRACT:

Importance

Patients with a history of cancer, even nonfatal cancers, have lower subsequent Alzheimer disease incidence. An inverse biological link between carcinogenesis and neurodegeneration has been hypothesized, although survival and detection biases are possible explanations.

Objective

To compare long-term memory trajectories before and after incident cancer with memory trajectories of similarly aged individuals not diagnosed with cancer.

Design, setting, and participants

This population-based cohort study included 14 583 US adults born before 1949 with no cancer history from the Health and Retirement Study. Biennial assessments were performed for up to 16 years from 1998 to 2014. Data analysis was performed from January 8 to October 5, 2018.

Exposures

Self

SUBMITTER: Ospina-Romero M 

PROVIDER: S-EPMC6593639 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature