Association of Genetic Risk for Rheumatoid Arthritis With Cognitive and Psychiatric Phenotypes Across Childhood and Adolescence.

ABSTRACT:

Importance

The association of rheumatoid arthritis (RA) with cognitive and psychiatric phenotypes has been recognized. However, it is not known whether these phenotypes are a consequence of disease-related factors, such as pain, or reflect shared etiological factors.

Objective

To investigate whether genomic risk for RA is associated with cognitive and psychiatric symptoms in children and adolescents.

Design, setting, and participants

This cohort study analyzed data from 3296 to 5936 adolescents (depending on outcome) from the Avon Longitudinal Study of Parents and Children. Clinical and questionnaire data were collected periodically from September 6, 1990, with collection ongoing, and analyzed from August 21, 2017, to May 21, 2018.

Exposures

Polygenic risk scor

SUBMITTER: Jones HJ 

PROVIDER: S-EPMC6593640 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature