Meta-analysis of the outcomes of treatment of internal carotid artery near occlusion.

ABSTRACT:

Background

Guidelines recommend treating patients with an internal carotid artery near occlusion (ICANO) with best medical therapy (BMT) based on weak evidence. Consequently, patients with ICANO were excluded from randomized trials. The aim of this individual-patient data (IPD) meta-analysis was to determine the optimal treatment approach.

Methods

A systematic search was performed in MEDLINE, EMBASE and the Cochrane Library databases in January 2018. The primary outcome was the occurrence of any stroke or death within the first 30 days of treatment, analysed by multivariable mixed-effect logistic regression. The secondary outcome was the occurrence of any stroke or death beyond 30 days up to 1 year after treatment, evaluated by Kaplan-Meier survival analysis.

Results

SUBMITTER: Meershoek AJA 

PROVIDER: S-EPMC6593672 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature