Expression of IL-7Rα and KLRG1 defines functionally distinct CD8⁺ T-cell populations in humans.

ABSTRACT: During acute viral infections in mice, IL-7Rα and KLRG1 together are used to distinguish the short-lived effector cells (SLEC; IL-7Rα^lo KLRG^hi ) from the precursors of persisting memory cells (MPEC; IL-7Rα^hi KLRG1^lo ). We here show that these markers can be used to define distinct subsets in the circulation and lymph nodes during the acute phase and in "steady state" in humans. In contrast to the T cells in the circulation, T cells derived from lymph nodes hardly contain any KLRG1-expressing cells. The four populations defined by IL-7Rα and KLRG1 differ markedly in transcription factor, granzyme and chemokine receptor expression. When studying renal transplant recipients experiencing a primary hCMV and EBV infection, we also found that after vira

SUBMITTER: Remmerswaal EBM 

PROVIDER: S-EPMC6593687 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature