Enhancing immunity prevents virus-induced T-cell-mediated immunopathology in B cell-deficient mice.

ABSTRACT: Hyper-activated or deviated immune responses can result in immunopathological diseases. Paradoxically, immunodeficiency represents a frequent cause of such immune-mediated pathologies. Immunopathological manifestations are commonly treated by immunosuppression, but in situations in which immunodeficiency is the basis of disease development, enhancing immunity may represent an alternative treatment option. Here, we tested this counterintuitive concept in a preclinical model using infection of mice with lymphocytic choriomeningitis virus (LCMV). Firstly, we demonstrate that infection of B-cell-deficient (B^-/- ) but not of wild-type (WT) mice with the LCMV strain Docile induced a rapid and fatal CD8⁺ T-cell-mediated immunopathological disease. Similar to WT mice, LCMV-in

SUBMITTER: Straub T 

PROVIDER: S-EPMC6593698 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature