Treatment-resistant depression as risk factor for substance use disorders-a nation-wide register-based cohort study.

ABSTRACT:

Background and aims

Treatment-resistant depression (TRD) is common among patients with major depressive disorder (MDD). MDD may increase the risk for developing substance use disorders (SUD). The aim of this study was to investigate the risk for developing SUD among patients with TRD compared with other depressed patients.

Design

Observational cohort study.

Setting

Nation-wide governmental health registers in Sweden.

Participants

All patients aged 18-69 years with an MDD diagnosis in specialized health care who had received at least one antidepressant prescription during 2006-14 were identified. Patients with at least three treatment trials within a single depressive episode were classified with TRD.

Measurements

Patients with TRD were compared with the

SUBMITTER: Brenner P 

PROVIDER: S-EPMC6593719 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature