β1 Integrin is essential for fascin-mediated breast cancer stem cell function and disease progression.

ABSTRACT: Breast cancer remains the second cause of tumor-related mortality in women worldwide mainly due to chemoresistance and metastasis. The chemoresistance and metastasis are attributed to a rare subpopulation with enriched stem-like characteristics, thus called Cancer Stem Cells (CSCs). We have previously reported aberrant expression of the actin-bundling protein (fascin) in breast cancer cells, which enhances their chemoresistance, metastasis and enriches CSC population. The intracellular mechanisms that link fascin with its downstream effectors are not fully elucidated. Here, loss and gain of function approaches in two different breast cancer models were used to understand how fascin promotes disease progression. Importantly, findings were aligned with expression data from actual breast canc

SUBMITTER: Barnawi R 

PROVIDER: S-EPMC6593770 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature