Bio-absorbable sealants for reinforcing the pancreatic stump after distal pancreatectomy are critical.

ABSTRACT:

Background

Bio-absorbable sealants are widely used to reduce the rate and severity of postoperative pancreatic fistulas after distal pancreatectomy. However, numerous clinical trials have failed to demonstrate their clinical benefit. We therefore investigated stability and bio-compatibility of absorbable sealants in vitro and in vivo.

Methods

In vitro, polymerized compounds were incubated in pancreatic juice before their stability was tested. In vivo, two compounds were used to seal the pancreatic stump after distal pancreatectomy in nine pigs. Burst pressure of the pancreatic stump, surgical outcome, histology of the pancreatic stump, systemic inflammation, and drain fluid was examined.

Results

Products based on fibrin or collagen were unstable in the presence of act

SUBMITTER: Kuhlbrey CM 

PROVIDER: S-EPMC6593819 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature