Congenital diaphragmatic hernia and exercise capacity, a longitudinal evaluation.

ABSTRACT:

Objective

Children with congenital diaphragmatic hernia (CDH) suffer from long-term pulmonary morbidity. Longitudinal data of exercise capacity in these children are lacking. We hypothesized that exercise capacity would be impaired in children with CDH and deteriorates over time. We evaluated exercise capacity and its determinants in CDH patients longitudinally until 12 years of age.

Design

Prospective longitudinal follow-up study in tertiary university hospital.

Patients

One hundred and fourteen children with CDH born between 1999 and 2012.

Methods

Exercise capacity was evaluated using the Bruce treadmill-protocol at the ages of 5, 8, and 12 years. Primary outcome parameter was standard deviation score (SDS) of maximal endurance time. Data were analyzed by usi

SUBMITTER: Toussaint-Duyster LCC 

PROVIDER: S-EPMC6593853 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature