Adipose glucocorticoid action influences whole-body metabolism via modulation of hepatic insulin action.

ABSTRACT: The connection between adipose glucocorticoid action and whole-body metabolism is incompletely understood. Thus, we generated adipose tissue-specific glucocorticoid receptor-knockout (Ad-GcR^-/-) mice to explore potential mechanisms. Ad-GcR^-/- mice had a lower concentration of fasting plasma nonesterified fatty acids and less hepatic steatosis. This was associated with increased protein kinase B phosphorylation and increased hepatic glycogen synthesis after an oral glucose challenge. High-fat diet (HFD)-fed Ad-GcR^-/- mice were protected against the development of hepatic steatosis and diacylglycerol-PKCε-induced impairments in hepatic insulin signaling. Under hyperinsulinemic-euglycemic conditions, hepatic insulin response was ∼10-fold higher in HFD-fed Ad-G

SUBMITTER: Abulizi A 

PROVIDER: S-EPMC6593882 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature