Ursodeoxycholic acid inhibits uptake and vasoconstrictor effects of taurocholate in human placenta.

ABSTRACT: Intrahepatic cholestasis of pregnancy (ICP) causes increased transfer of maternal bile acids to the fetus and an increased incidence of sudden fetal death. Treatment includes ursodeoxycholic acid (UDCA), but it is not clear if UDCA protects the fetus. This study explores the placental transport of the bile acid taurocholate (TC) by the organic anion-transporting polypeptide, (OATP)4A1, its effects on the placental proteome and vascular function, and how these are modified by UDCA. Various methodological approaches including placental villous fragments and Xenopus laevis oocytes were used to investigate UDCA transport. Placental perfusions and myography investigated the effect of TC on vasculature. The effects of acute TC exposure on placental tissue were investigated using quantitative pro

SUBMITTER: Lofthouse EM 

PROVIDER: S-EPMC6593889 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature