Reduced mitochondrial lipid oxidation leads to fat accumulation in myosteatosis.

ABSTRACT: Myosteatosis is the pathologic accumulation of lipid that can occur in conjunction with atrophy and fibrosis following skeletal muscle injury. Little is known about the mechanisms by which lipid accumulates in myosteatosis, but many clinical studies have demonstrated that the degree of lipid infiltration negatively correlates with muscle function and regeneration. Our objective was to determine the pathologic changes that result in lipid accumulation in injured muscle fibers. We used a rat model of rotator cuff injury in this study because the rotator cuff muscle group is particularly prone to the development of myosteatosis after injury. Muscles were collected from uninjured controls or 10, 30, or 60 d after injury and analyzed using a combination of muscle fiber contractility assessments

SUBMITTER: Gumucio JP 

PROVIDER: S-EPMC6593892 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature