Association of Estradiol and Visceral Fat With Structural Brain Networks and Memory Performance in Adults.

ABSTRACT:

Importance

Changes in estradiol during aging are associated with increased dementia risk. It remains unclear how estradiol supports cognitive health and whether risk factors, such as midlife obesity, are exacerbated by estrogen loss.

Objectives

To assess whether visceral adipose tissue (VAT) moderates the association between age and brain network structure and to investigate whether estradiol moderates the association between VAT and brain network structure.

Design, setting, and participants

Cross-sectional study of data from 974 cognitively healthy adults in Germany who participated in the Health Study of the Leipzig Research Centre for Civilization Diseases, a previously described population-based cohort study. Two moderation analyses were performed, including VAT a

SUBMITTER: Zsido RG 

PROVIDER: S-EPMC6593958 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature