CGRP and the Trigeminal System in Migraine.

ABSTRACT:

Objective

The goal of this narrative review is to provide an overview of migraine pathophysiology, with an emphasis on the role of calcitonin gene-related peptide (CGRP) within the context of the trigeminovascular system.

Background

Migraine is a prevalent and disabling neurological disease that is characterized in part by intense, throbbing, and unilateral headaches. Despite recent advances in understanding its pathophysiology, migraine still represents an unmet medical need, as it is often underrecognized and undertreated. Although CGRP has been known to play a pivotal role in migraine for the last 2 decades, this has now received more interest spurred by the early clinical successes of drugs that block CGRP signaling in the trigeminovascular system.

Design

This nar

SUBMITTER: Iyengar S 

PROVIDER: S-EPMC6593989 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature