Collagen type IV remodelling gender-specifically predicts mortality in decompensated cirrhosis.

ABSTRACT:

Background & aims

Remodelling of extracellular matrix is crucial in progressive liver fibrosis. Collagen type III desposition has been shown in acute decompensation. Extratracellular matrix is compiled of deposition of various components. The role of basement membrane collagen type IV in advanced cirrhosis and acute decompensation is unclear and investigated in this study.

Methods

Patients with decompensated cirrhosis from the prospective NEPTUN cohort (ClinicalTrials.gov Identifier: NCT03628807), who underwent transjugular intrahepatic portosystemic shunt procedure were included. Clinical and laboratory parameters, PRO-C4 and C4M levels were measured in blood samples from portal and hepatic veins just before transjugular intrahepatic portosystemic shunt placement.

Result

SUBMITTER: Lehmann J 

PROVIDER: S-EPMC6594031 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature