Effects of nilotinib on platelet function in patients with chronic myeloid leukemia in chronic phase.

ABSTRACT:

Background

Tyrosine kinases are highly expressed in platelets and play an important role in their activation process. Some studies have reported the blocking effects of tyrosine kinase inhibitors on different platelet functions.

Objectives

Evaluate the effects of nilotinib on platelets aggregation in 42 patients with chronic phase of CML and correlate the results with clinical and hematological parameters: age, complete blood count and presentation.

Patients and methods

This study was conducted on 42 patients diagnosed as Chronic Phase of Chronic Myeloid Leukemia based on clinical, morphological and cytogenetic study. All patients were on Nilotinib treatment and were attending the National Center of Hematology in Baghdad. About 9 mL of venous blood sample were collect

SUBMITTER: Alqasim AMZ 

PROVIDER: S-EPMC6594045 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature