When basal insulin is not enough: A dose-response relationship between insulin glargine 100 units/mL and glycaemic control.

ABSTRACT:

Aims

A post-hoc analysis to assess the impact in people with type 2 diabetes, of increasing doses of basal insulin on glycaemic measures, body weight and hypoglycaemia.

Research design and methods

We included data from prospective, randomized controlled treat-to-target trials of ≥24 weeks' duration in people with type 2 diabetes, uncontrolled on metformin and sulphonylureas, and treated with insulin glargine 100 units/mL (U100), who had at least six fasting plasma glucose (FPG) measurements. The impact of insulin dose on glycated haemoglobin (HbA1c) values, FPG, hypoglycaemia incidence (<3.9 mmol/L [70 mg/dL]), and body weight was analysed. A total of 458 participants from three eligible trials were included.

Results

The observed relationship between higher basal insu

SUBMITTER: Umpierrez GE 

PROVIDER: S-EPMC6594069 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature