Homocysteine and small vessel stroke: A mendelian randomization analysis.

ABSTRACT:

Objective

Trials of B vitamin therapy to lower blood total homocysteine (tHcy) levels for prevention of stroke are inconclusive. Secondary analyses of trial data and epidemiological studies suggest that tHcy levels may be particularly associated with small vessel stroke (SVS). We assessed whether circulating tHcy and B vitamin levels are selectively associated with SVS, but not other stroke subtypes, using Mendelian randomization.

Methods

We used summary statistics data for single-nucleotide polymorphisms (SNPs) associated with tHcy (n = 18), folate (n = 3), vitamin B₆ (n = 1), and vitamin B₁₂ (n = 14) levels, and the corresponding data for stroke from the MEGASTROKE consortium (n = 16,952 subtyped ischemic stroke cases and 404,630 noncases).

Results

SUBMITTER: Larsson SC 

PROVIDER: S-EPMC6594149 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature