A microparticle platform for STING-targeted immunotherapy enhances natural killer cell- and CD8⁺ T cell-mediated anti-tumor immunity.

ABSTRACT: Immunotherapies have significantly improved cancer patient survival, but response rates are still limited. Thus, novel formulations are needed to expand the breadth of immunotherapies. Pathogen associated molecular patterns (PAMPs) can be used to stimulate an immune response, but several pathogen recognition receptors are located within the cell, making delivery challenging. We have employed the biodegradable polymer acetalated dextran (Ace-DEX) to formulate PAMP microparticles (MPs) in order to enhance intracellular delivery. While treatment with four different PAMP MPs resulted in tumor growth inhibition, cyclic GMP-AMP (cGAMP) MPs were most effective. cGAMP MPs showed anti-tumor efficacy at doses 100-1000 fold lower than published doses of soluble cGAMP in two murine tumor models. Treat

SUBMITTER: Watkins-Schulz R 

PROVIDER: S-EPMC6594365 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature