SMI-Ribosome inactivating protein conjugates selectively inhibit tumor cell growth.

ABSTRACT: Cell-targeting conjugates of Saporin 6, a ribosome inactivating protein (RIP), were prepared using the Saporin Ala 157 Cys mutant, a small molecule inhibitor (SMI) of integrins α_vβ₃/α_vβ₅, and a potent cytotoxin, auristatin F (AF). The conjugates selectively and potently inhibited proliferation of tumor cells expressing the target integrins. We anticipate that the small molecule-RIP bioconjugate approach can be broadly applied using other small molecule drugs.

SUBMITTER: Roy S 

PROVIDER: S-EPMC6594371 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature