Membrane trafficking and exocytosis are upregulated in port wine stain blood vessels.

ABSTRACT:

Introduction

Port wine stain (PWS) is characterized as a progressive dilatation of immature venule-like vasculatures which result from differentiation-impaired endothelial cells. In this study, we aimed to identify the major biological pathways accounting for the pathogenesis of PWS.

Methods

Sequential windowed acquisition of all theoretical fragment ion mass spectra (SWATH-MS) was used to identify differentially expressed proteins in PWS lesions, followed by confirmative studies with immunohistochemistry, immunoblot and transmission electron microscopy (TEM).

Results

107 out of 299 identified proteins showed differential expressions in PWS lesions as compared to normal skin, mainly involving the functions of biosynthesis, membrane trafficking, cytoskeleton and cell a

SUBMITTER: Yin R 

PROVIDER: S-EPMC6594380 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature