Effect of Static Compression Loads on Intervertebral Disc: An in Vivo Bent Rat Tail Model.

ABSTRACT:

Objective

To evaluate how well different magnitudes of compression-induced degenerative changes using a bent rat tail model simulated human lumbar lordosis. It has been shown that compression plays an important role in intervertebral disc degeneration (IDD).

Methods

Sprague-Dawley rats (n = 25) were instrumented with a special compressive apparatus that was used to bend the intervertebral disc between the 8th and the 10th caudal vertebral bodies using two Kirschner wires inserted percutaneously into the middle of two tail vertebrae. Then, rats were divided into five different static compression loads (control, sham, 1.8 N, 4.5 N, and 7.2 N). The degeneration of the discs was evaluated by magnetic resonance imaging (MRI), histology, gene expression of anabolism and catabolism

SUBMITTER: Xia W 

PROVIDER: S-EPMC6594518 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature